Product Type: PEPTIDE
CAS: 946870-92-4
MW：7.6kD
molecular:
IGF-1 plays a crucial role in muscle regeneration. IGF-1 stimulates bothproliferation and differentiation of stem cells in an autocrine-paracrinemanner, although it induces differentiation to a much greater degree. IGF-1,when injected locally, increases satellite cell activity, muscle DNA, muscleprotein content, muscle weight and muscle cross sectional area. The importanceof IGF-1 lies in the fact that all of its apparent functions act to inducemuscle growth with or without overload although it really shines as a growthpromoter when combined with physical loading of the muscle.
IGF-1 also acts as an endocrine growth factorhaving an anabolic effect on distant tissues once released into the bloodstream by the liver. IGF-1 possesses the insulin-like property of inhibitingdegradation, but in addition can stimulate protein synthesis. The insulin-likeeffects are probably due to the similarity of the signaling pathways betweeninsulin and IGF-1 following ligand binding at the receptors.
The ability of IGF-I to stimulate proteinsynthesis resembles the action of GH, which was shown in separate studies onvolunteers to stimulate protein synthesis without affecting proteindegradation. Although it is often believed that the effects of GH are mediatedthrough IGF-1, this cannot be the case entirely. First, the effects of the twohormones are different, in that GH does not change protein degradation. Second,the effect of GH is observed with little or no change in systemic IGF-1concentrations. Age related muscle loss has been prevented with GH injections,however it is believed that this is accomplished through IGF-1.
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